Serie A leaders Napoli were knocked out of the Europa League on Thursday despite a 2-0 win at RB Leipzig, while Ciro Immobile's hat-trick sent Lazio into the last 16.
A 3-1 home defeat to the Bundesliga outfit last week left Napoli on the brink of elimination, goals from Piotr Zielinski and Lorenzo Insigne setting up a grandstand finish in the return fixture.
But it was not to be, Timo Werner's brace in the first leg proving enough to see RB Leipzig into the last 16 of the Europa League in what is the club's maiden European campaign.
There was better news for Napoli's Serie A rivals Lazio, though, as an Immobile treble - his third of the season - saw them emphatically overturn a first-leg deficit against Romanian side Steaua Bucharest.
First-leg loss leaves Napoli too much to do
Werner struck the second of his two goals at the Stadio San Paolo deep into added time and that effort from the Germany international proved the decisive moment.
Zielinski thumped in the rebound after Insigne's initial attempt was saved to give Napoli hope, but they could not find a second goal until the last five minutes.
Insigne got in front of his marker to nudge Napoli level on aggregate, but, despite intense pressure in the closing stages, RB Leipzig held firm to progress on away goals.
Immobile treble turns tie around for Lazio
Lazio had suffered a surprise 1-0 loss in the first leg in Romania, but the Serie A side came from behind to secure a comfortable 5-1 aggregate victory.
Ciro Immobile scored twice before half-time to reach 30 goals in all competitions for the season, with Bastos also on target as Simone Inzaghi's men routed Steaua 5-0 at the Stadio Olimpico.
Felipe Anderson struck after the interval to add to a comprehensive Lazio win, guaranteeing Serie A will be represented in Friday's last-16 draw, with Immobile wrapping up his hat-trick.
Denisov sends Lokomotiv through
Lokomotiv Moscow joined city rivals CSKA in the last 16 with a 1-0 win over Nice ensuring a 4-2 aggregate victory, Igor Denisov's well-taken finish deciding the encounter in the Russian capital.
A 3-1 win for Sporting CP in their first leg against Astana gave the Portuguese side a big advantage, which Bas Dost added to with an early header - his 10th aerial goal of the campaign.
Although Astana equalised, Bruno Fernandes struck a brace in a thrilling 3-3 draw that ensured Sporting went through with a 6-4 aggregate victory.
10 - Bas Dost scored his 10th headed goal for @Sporting_CP this season, having netted 26 goals this season in total. Giant.— OptaJohan (@OptaJohan) February 22, 2018
Lyon knock out 2015-16 semi-finalists
Spanish teams have a brilliant record in this competition, but 2015-16 semi-finalists Villarreal were knocked out by Lyon.
The Ligue 1 side led 3-1 after the first leg at home and when Jaume Costa was dismissed, Villarreal's hopes of a comeback were severely dashed - Bertrand Traore then on target to earn a 1-0 win and send Lyon through.
Elsewhere, goals from Michael Krmencik and Ales Cermak earned Viktoria Plzen a 2-0 win and 3-1 aggregate success against Partizan Belgrade, while Dynamo Kiev progressed on away goals after a 0-0 draw with AEK Athens.
21 de junio 2018
|Argentina 0 Croatia 3: Caballero drops clanger as Messi´s men are stunned|
|Funes Mori departs Everton to join Villarreal|
|Djokovic beats Dimitrov as Kyrgios lays down a marker|
|Relegated Verona appoint World Cup winner Grosso|
|Trotz named Islanders´ new coach|
|Matic and Serbia ready for ´hellish´ Switzerland clash|
|Fleetwood flounders as Gros takes Pulheim lead|
|No attacks on Neymar, pledges Costa Rica boss Ramirez|
|Giroud return brings structure to France, but again they disappoint|
|Brighton sign Sunderland goalkeeper Steele|
|Schmeichel and Eriksen blast ´exceptionally harsh´ VAR penalty|
|Nigeria´s young World Cup squad learning on the job - Rohr|
|Moody: England players need protection|
|France 1 Peru 0: Mbappe books last-16 spot with record goal|
|I don´t need anyone to hold my hand - Verstappen|
|Captaincy comes back around to Silva as 2014 pain fades|
|We don´t want to be losers - Petkovic|
|Alba not interested in Barcelona exit as Tottenham rumours swirl|
|BREAKING NEWS: Nagelsmann to take RB Leipzig role in 2019|
|Messi cannot be compared to Maradona, claims Argentina World Cup winner Kempes|
|Mbappe sets France record with maiden World Cup strike|
|Federer comes through tough Halle test|
|Nagelsmann to leave Hoffenheim amid RB Leipzig rumours|
|Gerrard brings former Liverpool team-mate Flanagan to Rangers|
|Cipriani to be ´the calmest guy in the room´ on England return|
|C´est magnifique! Lloris earns 100th France cap|
|Belgium v Tunisia: Hazard hoping for World Cup lift off|
|WATCH: Manchester United ditch piano to welcome Fred the red|
|Hamann springs to defence of Ozil|
|Alonso non-committal on future after Le Mans triumph|
|McInally returns to Scotland starting line-up|
|Giroud & Matuidi start as Deschamps drops Dembele for Peru|
|Torreira focused on Uruguay amid Arsenal links|
|NBA Mock Draft 2018: Deandre Ayton leads intriguing first round|
|Tite will not take away Neymar´s ´genius´|
|Australia show promise but calls for Cahill ignored amid lack of cutting edge|
|Manchester United means greatness - Fred aiming for titles following Old Trafford switch|
|Denmark 1 Australia 1: Jedinak strikes back after Eriksen rocket|
|Neymar not being put at risk by Brazil, says Tite|
|Juventus complete signing of free agent Emre Can|
|Fred completes Manchester United switch|
|Dembele will not join a Spurs rival|
|What were the 0.4 per cent doing? Iceland captain marvels at TV audience|
|Forsberg ready for ´next big step´ after RB Leipzig|
|´Retired´ Brits on bench as Springboks ring changes for final Test|
|Meninga: Key Kangaroos positions up for grabs in Origin|
|FIFA gets shirty over Ronaldo claims|
|Soyuncu keen on Arsenal switch|
|Atmosphere much better after criticism, says Hummels|
|FIFA issues statement after ´questionable´ Amrabat decision|
|Cipriani and Robshaw to start for England at Newlands|
|Team Sky hit back at Hinault´s ´irresponsible´ Froome comments|
|Iran fans are the real winners as women get glimpse of the future|
|Beckham predicts England-Argentina World Cup final|
|Napoli should sign Meret, Zenga claims|
|Meticulous Mouratoglou shaping stars of the future|
|Journalist hands Khedira boarding pass for early flight home|
|Germany v Sweden: Muller upbeat ahead of huge World Cup clash|
|South Korea v Mexico: Germany´s conquerors set for role reversal|
|Chandimal appeals against one-match ban|
|Fofana and Lamerat start, Parra skipper for final All Blacks Test|
|Asia and Africa being left behind - Queiroz|
|Emre Can arrives for Juventus medical|
|Championship fixtures: Bielsa´s Leeds face Stoke while Lampard´s Derby go to Reading|
|Tui handed first Wallabies start, five changes for Ireland|
|Sorensen: Denmark need to ´muscle up´ against Australia|
|Nolan Arenado helps Rockies power past Mets|
|Pavon set to be unleashed as Sampaoli plots Messi masterplan|
|Pique welcomes discussion with Barca hierarchy|
|Ramos hits back at Maradona|