Mauricio Pochettino says Barcelona or another club could "steal" Harry Kane from Tottenham.
Kane has been linked with Barca, who are reportedly seeking a long-term successor for Luis Suarez, despite signing a six-year contract before the World Cup, where he won the Golden Boot in England's run to the semi-finals.
Barca head coach Ernesto Valverde described Kane as "exceptional" ahead of Tuesday's Champions League meeting between the clubs at Camp Nou.
Kane has shown little public interest in leaving Spurs but Pochettino noted Premier League stars including Philippe Coutinho and Cristiano Ronaldo have previously been tempted to Spain.
"We have seen that many teams, both in LaLiga and the Premier League, have the economic capacity to steal a star from an important team," Pochettino told a news conference.
"It has happened in the past. Real Madrid signed Cristiano from Manchester United, Coutinho was taken off Liverpool. It has happened in different ways and it will happen in the future, I'm sure.
"But that does not only depend on the economic side, it also depends on the player's aspirations, sometimes they make decisions on facts, certain decisions force players to make decisions at times."
Spurs have also been linked with a move for Barca's rising star Riqui Puig, but Pochettino was unwilling to reveal if the 19-year-old midfielder is a target.
"I don't like to talk about rumours," he said. "Puig, I don't talk about youth players, there is no benefit, it's customary not to talk about these things."
Valverde told his pre-match news conference Suarez would not play, the former Liverpool striker having made a goalscoring return from a knee injury in a 4-0 LaLiga derby win at Espanyol on Saturday.
Suarez was later named in Barca's squad, along with other stars including Lionel Messi, although Valverde indicated he could take the chance to rest players with top spot in Group B already guaranteed.
"We play against Barcelona - I'm not focused on the starting 11," continued Pochettino, whose side must at least match Inter's result against PSV to advance.
"When you play for Barcelona there is always pressure to win - you play for something special. It's the same when you player for Tottenham, the names are not important.
"When you play Barcelona, the quality they have in the squad is amazing, different names have different qualities to add to the team, but they will be strong, they will try to beat us and for different reasons they will play for each other - it's not my business.
"For us, it should be the same motivation, approach, thinking to deliver our best job and try to win, that's how we need to approach the game."
Of Suarez's absence, he added: "Obviously it's an important miss for Barcelona. He's one of the best strikers in the world, together with Harry Kane. It's a shame he won't be playing.
"Suarez has proven in different countries, especially with Liverpool in England and at Barcelona, that he's one of the best strikers nowadays. Obviously, it is important - Barcelona are going to miss him."
16 de enero 2019
|Brown fires back at Arians over ´diva´ comments|
|Stone heading home from West Indies tour with back injury|
|Shazier will continue rehab with intention of playing again|
|That´s why we signed him! Allegri hails Supercoppa match-winner Ronaldo|
|Monaco on worst home run in club´s history after Nice draw|
|Atletico Madrid 3 Girona 3 (4-4 agg): Simeone´s side out on away goals|
|Gregg Williams is Jets´ new defensive coordinator|
|Ronaldo: Supercoppa triumph just the start for Juve|
|Monaco confirm Batshuayi talks|
|You know more than me! Bielsa´s Barcelona research surprised Guardiola|
|Juventus 1 AC Milan 0: Ronaldo heads Bianconeri to Supercoppa glory|
|Kane injury cannot be excuse for Tottenham – Pochettino|
|Woods to open 2019 schedule at Torrey Pines|
|Reported Liverpool target Dabbur to undergo Sevilla medical|
|Lebanon v North Korea: Radulovic calls on players to make history|
|MLS MVP Martinez signs five-year contract with Atlanta|
|WBC set deadline for Wilder-Fury rematch|
|Iran 0 Iraq 0: Team Melli top Group D after dull draw|
|Vietnam 2 Yemen 0: Quang Hai shines to give Golden Dragons hope|
|Bielsa admits to spying on all Leeds´ opponents|
|Valverde open to arrivals amid De Jong tug-of-war|
|Sexton named in Ireland squad for Six Nations openers|
|Higuain benched for Supercoppa Italiana amid Chelsea links|
|De Grandhomme, Latham and Santner back in Black Caps squad|
|Oman v Turkmenistan: Verbeek tells players to ´score as many as possible´|
|Japan v Uzbekistan: Cuper not distracted by potential last-16 opponents|
|Brown desperate for England recall|
|Lowry ties course record in Abu Dhabi|
|James is playing for Bayern future – Kovac|
|Wizards can compete for playoffs in LeBron-less East despite injuries - Brooks|
|Kyrgyzstan 3 Philippines 1: Lux hat-trick gives White Falcons third-place hope|
|South Korea 2 China 0: Son sets the standard as Bento´s men take top spot|
|Saudi Arabia v Qatar: Top spot on the line in Group E|
|Wasps pull off Fekitoa coup|
|Fresh injury woe for Real Madrid defender Vallejo|
|Home sweet home for Wozniacki as Stephens conquers Melbourne demons|
|Nadal: Victory over Ebden a step forward|
|Proteas rest Steyn and De Kock for opening ODIs|
|Nadal and Federer march on as rising stars prosper|
|Barcelona president Bartomeu convinced Valverde will stay|
|Inter forward Keita suffers thigh injury|
|Nadal races into third round with easy Ebden win|
|Kimmich ´perfect´ for Barcelona, says Xavi|
|Richardson and Nabi inspire Renegades´ rout of Sixers|
|This Liverpool isn´t a team of chokers – Mane|
|Central Coast Mariners 2 Melbourne City 1: Late Simon winner ends 10-match losing streak|
|Bryan backs Murray to return after hip resurfacing surgery|
|Scotland coach Townsend turns to trio of uncapped hookers|
|Spurs´ Aurier arrested on suspicion of assault, released without charge|
|That was a fireworks show - Warriors revel in record-breaking first quarter|
|We are in talks with Chelsea – Salihamidzic reiterates interest in Hudson-Odoi|
|´Proud´ Messi recognises impact of team-mates after reaching 400 LaLiga goals|
|Henry v Vieira: The Arsene Wenger proteges to move into coaching|
|Federer enjoys ´cat and mouse´ win over Evans|
|Wozniacki cruises through in Melbourne|
|Federer maintains perfect Australian Open second-round record|
|Warriors set NBA record, Butler´s 76ers rout Timberwolves|
|´I like the fact we beat them´ - 76ers´ Butler revels in win over Timberwolves|
|Murray says he´ll ´probably´ have operation|
|Australian Open tribute for Andy Murray surprises brother Jamie|
|Warriors score NBA record 51 points in first quarter against Nuggets|
|Panthers owner Tepper doesn´t rule out Newton missing 2019 because of shoulder injury|
|De Ligt will be world´s best centre-back – Koeman|
|Ronaldo a ´perfect machine´, says Gattuso|
|Barcelona? I can´t say anything - Stuani|
|Silva upbeat about Man City title chances|
|Celtics youngsters say Irving´s callout ´came from a good place´|
|NFL playoffs: Patrick Mahomes v Tom Brady|
|NFL playoffs: Jared Goff v Drew Brees|
|Sixers sign Brewer to 10-day contract|