Wolves moved six points clear at the top of the Championship thanks to a 3-1 victory over lowly Burton Albion.
With second-placed Cardiff City travelling to Derby County on Sunday, Nuno Espirito Santo's side seized the opportunity to extend their advantage at the summit.
However, the other top-six teams in action on Saturday all failed to win, with Fulham held 2-2 at home by QPR and Middlesbrough having to settle for a 1-1 draw at Brentford.
Aston Villa, meanwhile, suffered a second straight loss as they went down 1-0 at Bolton Wanderers, a result that moves Phil Parkinson's side further clear of the relegation zone.
Bristol City and Preston North End closed the gap on the play-off places with respective wins over Ipswich Town and Sunderland, who are now five points adrift of safety.
Reading's worrying slide continued with a 3-2 loss at Norwich City, while Sheffield Wednesday secured a last-gasp 2-1 triumph at Leeds United and Sheffield United fought out a 0-0 draw with Nottingham Forest.
DANCING WITH WOLVES
Benik Afobe scored twice as Wolves followed up Tuesday's 3-0 win over Reading by easing past relegation-threatened Burton at Molineux.
After Helder Costa had broken the deadlock, striker Afobe converted Ruben Neves' pass to double the home side's lead in the 41st minute.
Lloyd Dyer gave the visitors hope when he found the net back before the break, only for Afobe to grab his fourth goal in as many games since returning to the club on loan from Bournemouth.
CHASING PACK FLUFF THEIR LINES
Fulham missed the chance to put pressure on Cardiff as they let slip a two-goal lead against QPR at Craven Cottage.
Tom Cairney and Lucas Piazon scored in the first half to put the hosts on course for a fifth successive league victory.
However, after Massimo Luongo halved the deficit prior to the interval, Pawel Wszolek popped up with an 81st-minute equaliser to frustrate Fulham's push for automatic promotion.
The point is at least enough to move up to third in the standings, with Villa slipping down a spot after defeat at a snowy Bolton in the late kick-off.
Another derby comeback. A great second half performance, which I thought we could have knicked it at the end. Fans we ever so loud again! Also nice way to go into the international break for myself! See you in 2 weeks Qpr fans pic.twitter.com/keOMHLXkWU— Massimo Luongo (@MassLuongo) March 17, 2018
BLUES CRUISE AT HOME
Birmingham City boosted their hopes of climbing out of the bottom three with a resounding 3-0 triumph over Hull City at St Andrew's.
New manager Garry Monk picked up his first victory since taking charge thanks mainly to a brace from Jota.
Che Adams, who was recalled to the side to replace the injured Sam Gallagher, also found the net as the hosts moved level on points with nearest rivals Barnsley, who lost 2-0 at home to in-form Millwall.
23 de abril 2018
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|South Africa to test unbeaten home record vs Pakistan & Sri Lanka|
|Kerr: Ginobili should keep playing another two years|
|He keeps getting better and better - Henderson full of praise for PFA winner Salah|
|Roma v Liverpool: Giallorossi have chance to write positive headlines|
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|Vieira refuses to address Arsenal rumours and Wenger departure|
|Cueto lowers historic ERA in Giants´ win|
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|City´s Sane named PFA Young Player of the Year|
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22 de abril 2018
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|Koulibaly: Napoli have always believed in Scudetto|
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|Guardiola has no problem with Manchester City pitch invasion|
|Neymar must join Real Madrid to become the best - Rivaldo|
|There was no player better than De Bruyne - Guardiola backs City man for PFA award|
|Top managers should want Arsenal job, says Moyes|
|Manchester City boss Guardiola aiming to smash records following title triumph|
|Las Palmas relegated from LaLiga after 4-0 home defeat to Alaves|
|Archer and Gowtham combine for dramatic Royals victory|
|This won´t happen forever - dominant Nadal reflects on latest success|
|Andrew Bogut returns to Australia, signs with Sydney Kings|
|Manchester City break Premier League passing and possession records|
|Conte: Morata still important despite Giroud impact|
|Inter gave up against Chievo, admits Spalletti|
|Conte denies Mourinho rift ahead of FA Cup final|
|Levy claims fifth European Tour crown in Rabat|
|Diouf miss ´a turning point´ for both Stoke and Burnley|
|Hughes upset with lack of VAR after Southampton´s FA Cup loss|
|Manchester City 5 Swansea City 0: Guardiola´s champions turn on the style|
|Manchester United are FA Cup favourites, claims Chelsea boss Conte|
|United States and Czech Republic reach Fed Cup final|
|Rapid start sees Racing through to Champions Cup final|
|Benevento relegated after late Crotone winner|
|Jungels roars to Liege-Bastogne-Liege victory|
|I don´t need to die anymore - Wenger reflects on Arsenal ´funeral´|
|Hazard gives Conte a dazzling reminder of better days|
|Playing at Wembley is like playing in my garden - Giroud|
|Sevilla president casts doubt on future of Montella|
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|Chelsea 2 Southampton 0: Giroud and Morata book FA Cup final spot|