Frank Lampard knocked old boss Jose Mourinho out of the EFL Cup as Derby County beat Manchester United on penalties, while Burton Albion triumphed against Burnley.
Marouane Fellaini's late equaliser took Tuesday's tie to a shootout following a 2-2 draw at Old Trafford, with Scott Carson saving Phil Jones' poor penalty to complete a dramatic 8-7 success for the Championship side.
Harry Wilson and Jack Marriott had earlier struck for the Rams as Lampard enjoyed a memorable reunion with Mourinho, his manager at Chelsea.
United's rivals Manchester City made short work of League One side Oxford United as the holders progressed to the fourth round thanks to a 3-0 win.
Phil Foden helped to create goals for Gabriel Jesus and Riyad Mahrez before scoring his first goal for the club to wrap up a star performance.
Yeeeeeeessss @PhilFoden— Fernandinho (@fernandinho) September 25, 2018
Along with United's exit, the other big shock of the day came at Burton, where Burnley's awful cup competitions record under Sean Dyche continued with a 2-1 loss.
Kevin Long's header gave the Premier League team the lead, but League One Burton hit back through Liam Boyce, who then set up Jamie Allen for a late winner.
Penalties were needed in the all-Premier League tie at Molineux, with Danny Ward saving three spot-kicks after a goalless draw to book Leicester City a fourth-round berth at the expense of Wolves.
Go on the Warden Penalty saving masterclass @dan_ward52— James Maddison (@Madders10) September 25, 2018
Callum Wilson scored a 94th-minute winner to secure a 3-2 home victory for Bournemouth against Blackburn Rovers, while Andros Townsend struck twice as Crystal Palace won 3-0 at West Brom.
Jordan Rhodes' hat-trick booked Norwich City's progression with a 4-3 thriller at Wycombe Wanderers, with 15-year-old Harvey Elliott making his Fulham debut in their 3-1 win at Millwall.
Middlesbrough scored all four of their penalties to edge through in a shootout after drawing 2-2 with Preston North End, while Blackpool are in the last 16 after a 2-0 home win against 10-man QPR.
11 de diciembre 2018
|We have a plan - Ravens coach Harbaugh prepared for Flacco return|
|´It´s difficult to accept´ - Gracia calls for introduction of VAR|
|LaLiga press on with overseas match plan despite Barcelona withdrawal|
|PSG open Coupe de France defence at fifth-tier Pontivy|
10 de diciembre 2018
|Hazard backs Sterling as Neville reveals England star´s Euro 2016 concerns|
|Everton 2 Watford 2: Digne salvages draw with 96th-minute free-kick|
|Barcelona could ´steal´ Kane, says Pochettino|
|Oakland Raiders fire general manager McKenzie|
|Struggling Villarreal appoint Garcia Plaza as Calleja successor|
|Warriors assign Cousins to G League team|
|Barcelona pull out of plan to play LaLiga game in Miami|
|Pochettino to keep an eye on Inter when Spurs face Barcelona|
|Pochettino confirms Walker-Peters set to start against Barcelona|
|Denver Nuggets add free agent Young|
|Topping Group A no magic wand for an easy knockout draw, says Simeone|
|The cake has been made, now we need the cherry - Ancelotti targets repeat at Anfield|
|Lloris braced to face ´one of the best in history´ in Messi|
|Tuchel expects Neymar to face Red Star|
|Foden signs Manchester City deal to 2024|
|It happened to me! - Valverde laughs off Dembele timekeeping|
|´Projecting´ an Argentina return? Messi met with AFA president and Scaloni|
|Erasmus expects to leave head coach role after World Cup|
|Chelsea issue suspensions pending investigation into Sterling incident|
|Kane is extraordinary – Valverde hails reported Barcelona target|
|Man behind Naomi Osaka´s rise wins WTA Coach of the Year|
|England name unchanged Test squad as Willey returns for West Indies ODIs|
|Spalletti: No issue with Icardi watching Superclasico in Madrid|
|Klopp confirms 2013 talks with ´chatty´ Napoli president De Laurentiis|
|Sri Lanka spinner Dananjaya suspended due to illegal action|
|His reaction was just brilliant – Klopp praises Sterling for response to abuse|
|Gomez renewal a ´smart decision´ for both parties – Klopp|
|Magnificent Molinari named European Golfer of the Year|
|Barcelona best option for Frenkie de Jong, insists midfielder´s father|
|Gronkowski on Miami Miracle: ´Got to make that tackle´|
|Tottenham youngster Walker-Peters signs on until 2023|
|Juventus ´more of a family´ than Real Madrid - Ronaldo|
|Kingsley Coman contemplates retirement if injury nightmare continues|
|McVay ´sick´ over offensive failings as Rams coach takes blame for loss|
|Calleja axed as Villarreal coach|
|Kenyan Drake on Miami Miracle: I couldn´t let Gronk tackle me!|
|Ronaldo: I deserved Ballon d´Or, the numbers don´t lie|
|Rugby Australia to make Cheika decision this month|
|England defender Gomez signs new Liverpool deal|
|Ronaldo wants to see Messi follow him to Italy|
|Neymar happy to play in any position for PSG - Draxler|
|Paine insists he is ´fine´ after taking blow to finger|
|Ponzio: River players will be ´idolised´ for Libertadores success|
|Champions League permutations: How Inter, PSG and Liverpool can progress|
|Kohli: India were better and deserved to win|
|Bears shut down Goff, Rams|
|India survive dramatic finish against Australia|
|Klopp calls for electric Anfield atmosphere against Napoli|
|Saints clinch back-to-back NFC South titles, Bears trump Rams|
|Bucks improve to 2-0 against Raptors with win in Toronto|
|Black Caps include Patel for Sri Lanka Tests|
|Maidana: River want Real Madrid clash|
|Cowboys top Eagles in OT behind stellar Cooper display|
|AC Milan evaluating Fabregas signing – Leonardo|
|WATCH: Steelers´ chance at game-tying field goal slips away|
|Hayne will plead not guilty to charges, says lawyer|
|Boca boss Schelotto: The only thing I feel is sadness|
|Cardinals´ Fitzgerald makes NFL history with most receptions for one team|
|River Plate´s Copa Libertadores star Gonzalo Martinez confirms January departure|
|Klopp: I was never worried about Salah´s form|
|Packers QB Rodgers sets NFL record for most passes without an interception|
|World Cup bulking hampered Man United form – Lukaku|
|Leonardo rules out Ibrahimovic Milan return|
|Warriors´ Green to return against Timberwolves|
|I feel for him… we´ll make it work – Butler responds to Embiid´s frustration|
|Torino draw no missed opportunity for misfiring AC Milan, claims Gattuso|